Frontiers of health: Catching rule-breakers

Celeste Nelson is out to determine the rules that govern normal development so she can stop the cancer cells that don't play by them. Currently studying mammary gland development and breast cancer at the Lawrence Berkeley National Laboratory, Nelson is funded by a Burroughs Wellcome Fund Career Award at the Scientific Interface. She will join the University faculty in the fall as an assistant professor of chemical engineering.

Frontiers of health: Sorting the 'biological haystack'

Ten years ago, it would take ten days for Princeton biologist Edward Cox to separate a million base pair fragments of DNA by size -- soon, he may be able to do it ten seconds, thanks to micron-sized devices being developed by a team of engineers, biologists and physicists.

Frontiers of health: Durable drugs

Fundamental approach targets practical problem Designing effective drugs and vaccines to combat and prevent disease is only half the battle—they also have to be formulated effectively for shipping and storage, which is where Pablo Debenedetti and Athanassios Panagiotopoulos come in. The chemical engineering professors use a combination of theoretical, computational and experimental techniques to explore how proteins behave in the presence of certain sugars that are often used as stabiliz

Frontiers of health: Treating cancer and HIV

Aerospace engineer Robert Stengel remembers the day he realized that the theories and analyses that make space travel possible may also lead to better understanding and treatments of cancer and HIV.

Frontiers of health: Killer proteins

Powerful proteins that are able to kill bacteria and viruses already exist in nature, but Kyle Vanderlick wants to make them even stronger. The chair of the chemical engineering department, Vanderlick conducts research on antimicrobial peptides -- short proteins that destroy disease-causing bugs by breaking down the membranes that surround them. The work, done in collaboration with biologists at the University of California, Irvine, could ultimately lead to the development of powerful new mic

Latrobe Prize supports plan to transform upper New York Harbor

One of the most coveted prizes in architecture was awarded in March to a team of Princeton architects and engineers for an ambitious plan to transform the Upper Bay of New York Harbor. The Latrobe Prize, a $100,000 purse awarded every other year by the American Institute of Architects, went to Princeton’s Center for Architecture, Urbanism and Infrastructure. The winning project team is led by Guy Nordenson, professor of architecture and affiliated professor of civil and environmental engi

Quest for ancient coins inspires a book and a course

Computer scientist Ken Steiglitz is happy to admit that he is an eBay addict. For starters, his pre-dawn "grazing" on the popular Internet trading site has yielded a trove of ancient bronze coins to add to his personal collection. Even more, he has discovered a wealth of information to advance the field of auction theory, which lies at the intersection of computer science, economics, mathematics and psychology.

Frontiers of health: New spin on heart valves

In a roundabout way, propellers advanced Julie Young's latest project—a new and improved heart valve replacement. "The blades of a propeller look very much like the leaflets in a mechanical heart valve," said Young, an assistant professor of civil and environmental engineering, who studied propellers for her Ph.D. dissertation at the University of Texas at Austin. "The same principles apply on a much smaller scale."

Frontiers of health: Moving pictures

Advances in medical imaging have added a new dimension, literally, to the research of Peter Ramadge, chair of electrical engineering. Rather than working with two-dimensional videos from cameras (his longtime area of expertise), Ramadge is analyzing three-dimensional movies of brain activity that are collected by a functional magnetic resonance imaging (fMRI) scanner. His work, in collaboration with the Center for the Study of Brain Mind and Behavior of the newly created Princeton Neuroscienc

Frontiers of health: Detecting disease

Medical devices that require nothing more than a single breath to instantaneously detect a number of ailments, including diabetes and kidney disease, are just what the doctor ordered. And, they are exactly what researchers are developing as part of the Center for Mid- Infrared Technologies for Health and the Environment (MIRTHE). Claire Gmachl